Pregnancy-Associated Plasma Protein-A Accelerates Atherosclerosis by Regulating Reverse Cholesterol Transport and Inflammation
نویسندگان
چکیده
منابع مشابه
Reverse cholesterol transport and atherosclerosis regression.
Cholesterol is the major component of atherosclerotic plaque. Cholesterol accumulation within atherosclerotic plaque occurs when cholesterol influx into the arterial wall (from apoB-containing lipoproteins) exceeds cholesterol efflux. Increased influx of cholesterol into the arterial wall is accompanied by an increased influx of monocytes/macrophages,1 which take up oxidized and aggregated LDL ...
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Atherosclerosis is characterized by a chronic inflammatory condition, in which numerous cellular and molecular inflammatory components are involved. A wide array of inflammatory mediators, such as cytokines and proteins produced by macrophages and other cells, play critical roles in the development and progression of the disease. ABCA1 is crucial for cellular cholesterol efflux and reverse chol...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2019
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-18-0700